柱晶白霉素及其类似物对[14C]红霉素与大肠杆菌核糖体结合的影响。
Effect of leucomycins and analogues on binding [14C ]erythromycin to Escherichia coli ribosomes.
作者信息
Pestka S, Nakagawa A, Omura S
出版信息
Antimicrob Agents Chemother. 1974 Nov;6(5):606-12. doi: 10.1128/AAC.6.5.606.
Abstract
We examined the effect of leucomycins, leucomycin derivatives, and other 16-membered macrolides (tylosin, niddamycin, spiramycin I, and spiramycin III) on [(14)C]erythromycin binding to ribosomes. Results of these studies enabled determination of the association and dissociation constants for the binding of each of these compounds to Escherichia coli ribosomes. In addition, the binding of the leucomycins and the leucomycin derivatives to ribosomes in general correlated with their antimicrobial activity.
摘要
我们研究了柱晶白霉素、柱晶白霉素衍生物以及其他16元大环内酯类抗生素（泰乐菌素、尼达霉素、螺旋霉素I和螺旋霉素III）对[¹⁴C]红霉素与核糖体结合的影响。这些研究结果能够确定这些化合物与大肠杆菌核糖体结合的缔合常数和解离常数。此外，柱晶白霉素和柱晶白霉素衍生物与核糖体的结合总体上与其抗菌活性相关。
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