红霉素类似物对完整细菌及[14C]红霉素与大肠杆菌核糖体结合的作用相关性
Correlation of effects of erythromycin analogues on intact bacteria and on [14C]erythromycin binding to Escherichia coli ribosomes.
作者信息
Pestka S, Lemahieu R, Miller P
出版信息
Antimicrob Agents Chemother. 1974 Oct;6(4):489-91. doi: 10.1128/AAC.6.4.489.
Abstract
The dissociation constants for binding to ribosomes from Escherichia coli and concentrations at which 50% inhibition of [(14)C]erythromycin binding to ribosomes occurred were determined for 45 erythromycin analogues. These values were correlated with their antibacterial activities against Bacillus subtilis. Compounds which bound to ribosomes best showed the greatest activities; those which were poorly bound to ribosomes showed little or no antibacterial activity. The ribosomal binding assays therefore reflected the general antibacterial potential of the erythromycin analogues.
摘要
测定了45种红霉素类似物与大肠杆菌核糖体结合的解离常数以及对[¹⁴C]红霉素与核糖体结合产生50%抑制作用时的浓度。这些值与它们对枯草芽孢杆菌的抗菌活性相关。与核糖体结合最佳的化合物显示出最大的活性；与核糖体结合不佳的化合物显示出很少或没有抗菌活性。因此，核糖体结合试验反映了红霉素类似物的总体抗菌潜力。
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引用本文的文献
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本文引用的文献
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Mode of action of macrolides.大环内酯类药物的作用机制。
Biochim Biophys Acta. 1968 Apr 22;157(2):404-13. doi: 10.1016/0005-2787(68)90094-4.
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J Mol Biol. 1969 Sep 14;44(2):347-61. doi: 10.1016/0022-2836(69)90180-6.
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Sensitivity and resistance to erythromycin in Bacillus subtilis 168: the ribosomal binding of erythromycin and chloramphenicol.枯草芽孢杆菌168对红霉素的敏感性和抗性：红霉素与氯霉素的核糖体结合
Biochim Biophys Acta. 1966 Aug 17;123(2):438-40. doi: 10.1016/0005-2787(66)90301-7.
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Inhibitors of ribosome functions.核糖体功能抑制剂。
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Antimicrob Agents Chemother. 1974 Oct;6(4):474-8. doi: 10.1128/AAC.6.4.474.
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