Sreedhara Swamy K H, Sirsi M, Ramananda Rao G R
Antimicrob Agents Chemother. 1974 Apr;5(4):420-5. doi: 10.1128/AAC.5.4.420.
The antifungal drug, miconazole nitrate, inhibits the growth of several species of Candida. Candida albicans, one of the pathogenic species, was totally inhibited at a concentration of approximately 10 mug/ml. Endogenous respiration was unaffected by the drug at a concentration as high as 100 mug/ml, whereas exogenous respiration was markedly sensitive and inhibited to an extent of 85%. The permeability of the cell membrane was changed as evidenced by the leakage of 260-nm absorbing materials, amino acids, proteins, and inorganic cations. The results we present clearly show that the drug alters the cellular permeability, and thus the exogenous respiration becomes sensitive to the drug.
抗真菌药物硝酸咪康唑可抑制多种念珠菌的生长。致病性念珠菌之一白色念珠菌在浓度约为10微克/毫升时被完全抑制。在浓度高达100微克/毫升时，内源性呼吸不受该药物影响，而外源性呼吸则明显敏感，受到85%程度的抑制。细胞膜的通透性发生了变化，这可通过260纳米吸收物质、氨基酸、蛋白质和无机阳离子的泄漏得到证明。我们给出的结果清楚地表明，该药物改变了细胞通透性，因此外源性呼吸对该药物变得敏感。
