Merati Albert L, Lim Hyun J, Ulualp Seckin O, Toohill Robert J
Department of Otolaryngology and Communication Sciences and the Division of Biostatistics, The Medical College of Wisconsin, Milwaukee, Wisconsin 53226-0099, USA.
Ann Otol Rhinol Laryngol. 2005 Mar;114(3):177-82. doi: 10.1177/000348940511400302.
We report a meta-analysis of a series of studies in which 24-hour ambulatory pH monitoring was performed in 1) normal subjects, 2) the normal control subjects in studies of laryngopharyngeal reflux (LPR), and 3) the patients with LPR in these controlled studies. The statistical analysis utilized the fixed-effects model by Mantel-Haenszel and the random-effects mixed model. There were 16 studies from the past 12 years that fulfilled the inclusion criteria. They involved 793 subjects (264 normal and 529 with LPR). The numbers of positive pharyngeal reflux events for normal subjects and for patients with LPR differed with a p value of <.0001. There was also a significant difference in the mean percentage of acid exposure times between normal subjects and patients with LPR (p = .003). We conclude that the upper probe gives accurate and consistent information in normal subjects and patients with LPR. The numbers of reflux events and acid exposure times are most important in distinguishing normal subjects from patients with LPR. The technology and methodology of probe testing is quite reliable and is consistent on a worldwide basis.
我们报告了一系列研究的荟萃分析，这些研究对以下三组对象进行了24小时动态pH监测：1）正常受试者；2）喉咽反流（LPR）研究中的正常对照受试者；3）这些对照研究中的LPR患者。统计分析采用了Mantel-Haenszel固定效应模型和随机效应混合模型。过去12年中有16项研究符合纳入标准。这些研究涉及793名受试者（264名正常受试者和529名LPR患者）。正常受试者和LPR患者的咽反流阳性事件数量不同，p值<0.0001。正常受试者和LPR患者之间的酸暴露时间平均百分比也存在显著差异（p = 0.003）。我们得出结论，上探头在正常受试者和LPR患者中能提供准确且一致的信息。反流事件数量和酸暴露时间对于区分正常受试者和LPR患者最为重要。探头测试的技术和方法相当可靠，并且在全球范围内是一致的。
