经颅磁刺激研究空间注意对人类感觉运动整合的影响。
Effect of spatial attention on human sensorimotor integration studied by transcranial magnetic stimulation.
作者信息
Kotb Mamdouh Ali, Mima Tatsuya, Ueki Yoshino, Begum Tahamina, Khafagi Amal Tawfik, Fukuyama Hidenao, Nagamine Takashi
机构信息
Human Brain Research Center, Kyoto University Graduate School of Medicine, Japan.
出版信息
Clin Neurophysiol. 2005 May;116(5):1195-200. doi: 10.1016/j.clinph.2004.12.006. Epub 2005 Jan 24.
OBJECTIVE
Recent transcranial magnetic stimulation (TMS) studies showed that the sensory input can decrease the motor cortex excitability (afferent inhibition). To clarify the effect of attention on sensorimotor integration, we investigated the effect of spatial attention on afferent inhibition.
METHODS
Right median nerve electrical stimulation followed, at variable delays (10-300 ms), by TMS over the left motor cortex was applied to 9 subjects, during 3 conditions; spatial attention to the right and left hand, and control (no attention) tasks.
RESULTS
Inhibition of the motor evoked potential occurred at inter-stimulus interval of 20 and 100 ms, which was more was marked during spatial attention to the right than to the left hand.
CONCLUSIONS
Enhancement of the afferent inhibition induced by spatial attention to the stimulated side is likely to reflect the interaction between attention and sensorimotor integration.
SIGNIFICANCE
The spatial attention may modulate the sensorimotor integration studied by afferent inhibition of the MEP.
目的
近期经颅磁刺激（TMS）研究表明，感觉输入可降低运动皮层兴奋性（传入抑制）。为阐明注意力对感觉运动整合的影响，我们研究了空间注意力对传入抑制的作用。
方法
对9名受试者在3种条件下进行如下操作：通过对右侧正中神经进行电刺激，并在不同延迟时间（10 - 300毫秒）后，对左侧运动皮层施加TMS；这3种条件分别为对右手和左手的空间注意力任务，以及对照（无注意力）任务。
结果
在刺激间隔为20和100毫秒时出现运动诱发电位抑制，且在对右侧的空间注意力任务中比在对左侧手的任务中更明显。
结论
对受刺激侧的空间注意力所诱导的传入抑制增强，可能反映了注意力与感觉运动整合之间的相互作用。
意义
空间注意力可能调节通过对运动诱发电位的传入抑制所研究的感觉运动整合。
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