非洲黑人儿童中与人类免疫缺陷病毒感染相关的关节炎：是因果关系还是巧合？
Arthritis in association with human immunodeficiency virus infection in Black African children: causal or coincidental?
作者信息
Chinniah K, Mody G M, Bhimma R, Adhikari M
机构信息
Department of Paediatrics and Child Health, Nelson R. Mandela School of Medicine, University of KwaZulu Natal, Private Bag X7, Congella, 4013, South Africa.
出版信息
Rheumatology (Oxford). 2005 Jul;44(7):915-20. doi: 10.1093/rheumatology/keh636. Epub 2005 Apr 12.
OBJECTIVES
To compare human immunodeficiency virus (HIV)-infected and HIV-uninfected children with arthritis of unknown origin to determine whether the association between HIV infection and arthritis is causal or coincidental.
METHOD
Retrospective review of 132 children with arthritis who were tested for HIV infection.
RESULTS
Thirty-five (27%) of the children were HIV infected and the male to female ratio was 2.5:1 (P = 0.02). Arthritis was the presenting feature of HIV infection in 78% of these children. The remaining 97 (73%) were diagnosed as having juvenile idiopathic arthritis. 'Spondyloarthropathy-like' features were found in 34% of HIV-infected children compared with 5% of uninfected children.
CONCLUSION
The high prevalence of HIV infection in 27% of children, the predominance of males and the increased prevalence of 'spondyloarthropathy-like' features, supports a causal relationship between HIV infection and arthritis.
目的
比较感染人类免疫缺陷病毒（HIV）和未感染HIV的不明原因关节炎患儿，以确定HIV感染与关节炎之间的关联是因果关系还是偶然巧合。
方法
对132例接受HIV感染检测的关节炎患儿进行回顾性研究。
结果
35例（27%）患儿感染HIV，男女比例为2.5:1（P = 0.02）。在这些患儿中，78%的患儿关节炎是HIV感染的首发症状。其余97例（73%）被诊断为幼年特发性关节炎。34%的HIV感染患儿出现“脊柱关节病样”特征，而未感染患儿中这一比例为5%。
结论
27%的患儿中HIV感染率高、男性占优势以及“脊柱关节病样”特征患病率增加，支持HIV感染与关节炎之间存在因果关系。
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