Rowley Benjamin, Monestier Marc
Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, PA 19140, USA.
Mol Immunol. 2005 May;42(7):833-8. doi: 10.1016/j.molimm.2004.07.050.
Chemical exposure can trigger or accelerate the development of autoimmune manifestations. Although heavy metals are elementary chemical structures, they can have profound and complex effects on the immune system. In genetically susceptible mice or rats, administration of subtoxic doses of mercury induces both the production of highly specific autoantibodies and a polyclonal activation of the immune system. We review in this article some of the mechanisms by which heavy metal exposure can lead to autoimmunity.
化学物质暴露可引发或加速自身免疫表现的发展。尽管重金属是基本的化学结构，但它们可对免疫系统产生深远而复杂的影响。在基因易感的小鼠或大鼠中，给予亚毒性剂量的汞可诱导产生高度特异性自身抗体以及免疫系统的多克隆激活。我们在本文中综述了重金属暴露可导致自身免疫的一些机制。
