Potter M
Laboratory of Genetics, National Cancer Institute, Bethesda, Maryland.
Hematol Oncol Clin North Am. 1992 Apr;6(2):211-23.
The natural history of multiple myeloma and related human plasma cell tumors is compared to the process of plasmacytomagenesis in mice. Intriguing new findings are beginning to give a more complete picture of the evolution of these tumors. Mouse plasmacytomas consistently develop chromosomal translocations that dysregulate c-myc, but consistent oncogenic mutations have not yet been defined in multiple myeloma.
