Ishimitsu Toshihiko, Ohta Satoshi, Saito Mayumi, Teranishi Megumi, Inada Hideki, Yoshii Masayoshi, Minami Junichi, Ono Hidehiko, Hikawa Akihisa, Shibata Norio, Sugaya Takeshi, Kamijo Atsuko, Kimura Kenjiro, Ohrui Masami, Matsuoka Hiroaki
Department of Cardiovascular Medicine, Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi 321-0293, Japan.
Clin Exp Nephrol. 2005 Mar;9(1):34-9. doi: 10.1007/s10157-004-0331-x.
Messenger RNA of liver fatty acid-binding protein (L-FABP) is expressed in proximal tubules of the kidney, and a certain amount is excreted into urine. We analyzed factors relating to the urinary L-FABP excretion in health-check participants.
We measured L-FABP in the first morning urine by ELISA in 715 men and 193 women 30-79 years of age who entered a 2-day hospitalized health checkup program. In addition to the routine physical examination and laboratory tests, plasma high-sensitivity C-reactive protein (HSCRP) was assayed.
In 150 healthy subjects, urinary L-FABP averaged 3.6 +/- 0.2 microg/g creatinine, whereas the values were significantly increased in patients with hypertension (5.2 +/- 0.4, P = 0.010), diabetes mellitus (5.5 +/- 0.5, P < 0.001), and chronic hepatitis (5.8 +/- 1.0, P = 0.022). Urinary L-FABP excretion was significantly greater in women than in men when the value was related to creatinine. In regression analysis in men, urinary L-FABP was positively correlated with fasting plasma glucose (r = 0.103, P = 0.033) and plasma HSCRP (r = 0.135, P = 0.006).
It is suggested that renal production and urinary excretion of L-FABP are increased in situations in which arteriosclerosis is promoted, such as hypertension, diabetes mellitus, and cardiovascular inflammation.
肝脏脂肪酸结合蛋白（L-FABP）的信使核糖核酸在肾脏近端小管中表达，且有一定量会排泄到尿液中。我们分析了健康体检参与者中与尿L-FABP排泄相关的因素。
我们采用酶联免疫吸附测定法（ELISA），对715名年龄在30至79岁之间的男性和193名女性进行了为期2天的住院健康检查，测量了他们晨尿中的L-FABP。除了常规体检和实验室检查外，还检测了血浆高敏C反应蛋白（HSCRP）。
在150名健康受试者中，尿L-FABP平均为3.6±0.2微克/克肌酐，而高血压患者（5.2±0.4，P = 0.010）、糖尿病患者（5.5±0.5，P < 0.001）和慢性肝炎患者（5.8±1.0，P = 0.022）的值显著升高。当与肌酐相关时，女性的尿L-FABP排泄量明显高于男性。在男性的回归分析中，尿L-FABP与空腹血糖（r = 0.103，P = 0.033）和血浆HSCRP（r = 0.135，P = 0.006）呈正相关。
提示在高血压、糖尿病和心血管炎症等促进动脉粥样硬化的情况下，肾脏L-FABP的产生和尿排泄增加。
