稳定期哮喘和慢性阻塞性肺疾病中肺炎支原体和肺炎衣原体的血清流行率。
Seroprevalence of Mycoplasma pneumoniae and Chlamydia pneumoniae in stable asthma and chronic obstructive pulmonary disease.
作者信息
Park Seoung-Ju, Lee Yong-Chul, Rhee Yang-Keun, Lee Heung-Bum
机构信息
Department of Internal Medicine, Chonbuk National University Medical School, Jeonju 561-712, Korea.
出版信息
J Korean Med Sci. 2005 Apr;20(2):225-8. doi: 10.3346/jkms.2005.20.2.225.
Mycoplasma pneumoniae and Chlamydia pneumoniae have been suggested to take part in the acute exacerbation of bronchial asthma and chronic obstructive pulmonary disease (COPD). Several studies have questioned whether they may play pathogenic roles in connection with bronchial asthma and COPD. This study was designed to evaluate the seroprevalences of M. pneumoniae and C. pneumoniae in stable asthma and COPD patients, and to compare with control patients. The medical records of one hundred forty patients who underwent M. pneumoniae and C. pneumoniae serology were retrospectively reviewed. Seroprevalences of M. pneumoniae and C. pneumoniae in the asthma group (11.1% and 8.3%, respectively) were higher than in the control group (4.4% and 2.2%, respectively) without statistical significance. The seroprevalence of M. pneumoniae in the COPD group (16.9%) was significantly higher than in the control group, and the seroprevalence of C. pneumoniae in the COPD group (3.4%) was higher than in the control group without statistical significance. This study raises important questions about the relation of M. pneumoniae and C. pneumoniae infection with stable asthma or COPD.
肺炎支原体和肺炎衣原体被认为与支气管哮喘和慢性阻塞性肺疾病（COPD）的急性加重有关。一些研究对它们是否可能在支气管哮喘和COPD中发挥致病作用提出了质疑。本研究旨在评估稳定期哮喘和COPD患者中肺炎支原体和肺炎衣原体的血清阳性率，并与对照患者进行比较。回顾性分析了140例接受肺炎支原体和肺炎衣原体血清学检测患者的病历。哮喘组中肺炎支原体和肺炎衣原体的血清阳性率分别为11.1%和8.3%，高于对照组（分别为4.4%和2.2%），但无统计学意义。COPD组中肺炎支原体的血清阳性率（16.9%）显著高于对照组，COPD组中肺炎衣原体的血清阳性率（3.4%）高于对照组，但无统计学意义。本研究对肺炎支原体和肺炎衣原体感染与稳定期哮喘或COPD的关系提出了重要问题。
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