慢性阻塞性肺疾病患者中百日咳博德特氏菌的高血清阳性率：一项病例对照研究
High Seroprevalence of Bordetella pertussis in Patients with Chronic Obstructive Pulmonary Disease: A Case-Control Study.
作者信息
Hashemi Seyyed Hamid, Nadi Ebrahim, Hajilooi Mehrdad, Seif-Rabiei Mohammad-Ali, Samaei Atefeh
机构信息
Brucellosis Research Center, Hamedan University of Medical Sciences, Hamedan, Iran,; Department of Infectious Diseases, Hamedan University of Medical Sciences, Hamedan, Iran.
Department of Internal Medicine, Division of Pulmonary Diseases, Hamedan University of Medical Sciences, Hamedan, Iran.
出版信息
Tanaffos. 2015;14(3):172-6.
BACKGROUND
Bordetella pertussis has been suggested to take part in the acute exacerbation of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the association between B. pertussis and COPD.
MATERIALS AND METHODS
In this case-control study, 90 patients with COPD and 90 age- and sex- matched control subjects were included. Serum samples were tested for anti-B. pertussis IgG and IgA by ELISA. A physician completed a questionnaire including demographic characteristics, habitual history and spirometric findings for each patient.
RESULTS
Of 90 patients with chronic obstructive pulmonary disease, 66 (51%) had mild, 31 (34.4%) had moderate, and 13 (14.4%) had severe disease. There was no significant association between B. pertussis IgA seropositivity and COPD. Serum levels of anti- B. pertussis IgG were significantly higher in patients with COPD than in the control subjects (P < 0.001). No association was observed between B. pertussis infection and severity of COPD.
CONCLUSION
The results suggest that there is an association between B. pertussis infection and COPD. Further studies should be planned to investigate the potential pathogenic mechanisms underlying these associations.
背景
有人提出百日咳博德特氏菌参与慢性阻塞性肺疾病（COPD）的急性加重。本研究的目的是调查百日咳博德特氏菌与COPD之间的关联。
材料与方法
在这项病例对照研究中，纳入了90例COPD患者和90例年龄及性别匹配的对照者。通过酶联免疫吸附测定法（ELISA）检测血清样本中的抗百日咳博德特氏菌IgG和IgA。一名医生为每位患者填写了一份包括人口统计学特征、习惯史和肺量计检查结果的问卷。
结果
90例慢性阻塞性肺疾病患者中，66例（51%）为轻度，31例（34.4%）为中度，13例（14.4%）为重度。百日咳博德特氏菌IgA血清阳性与COPD之间无显著关联。COPD患者血清抗百日咳博德特氏菌IgG水平显著高于对照者（P<0.001）。未观察到百日咳博德特氏菌感染与COPD严重程度之间的关联。
结论
结果表明百日咳博德特氏菌感染与COPD之间存在关联。应计划进一步研究以调查这些关联背后的潜在致病机制。
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