Schneider Steffen, Deckardt Klaus, Hellwig Juergen, Küttler Karin, Mellert Werner, Schulte Stefan, van Ravenzwaay Bennard
Department of Product Safety, BASF Aktiengesellschaft, 67056 Ludwigshafen, Germany.
Food Chem Toxicol. 2005 Jul;43(7):1083-92. doi: 10.1016/j.fct.2005.02.013.
Wistar rats continuously received octyl methoxycinnamate (OMC) in the diet through two successive generations at nominal doses of 0, 150, 450 or 1000 mg/kg bw/day. OMC had no adverse effects on estrous cycles, mating behavior, conception, parturition, lactation and weaning, sperm and follicle parameters, macropathology and histopathology of the sexual organs. 1000 mg/kg bw/day reduced parental food consumption and body weight (-14% to -16% in males, -4% to -5% females), increased liver weight, produced hepatic cytoplasmic eosinophilia and erosion/ulceration of glandular stomach mucosa. and led to a slightly decreased implantation rate in the top dose F0 and F1 dams. The high dose F1 and F2 pups had reduced lactation weight gain and organ weights and delayed sexual maturation landmarks. There was no evidence of a selective influence of the test compound on pups' sexual landmarks. The NOAEL (no observed adverse effect level) is 450 mg/kg bw/day for fertility and reproductive performance, for systemic parental and developmental toxicity.
Wistar大鼠连续两代在饮食中摄入桂皮酸盐（OMC），名义剂量分别为0、150、450或1000毫克/千克体重/天。OMC对发情周期、交配行为、受孕、分娩、哺乳和断奶、精子和卵泡参数、性器官大体病理学和组织病理学均无不良影响。1000毫克/千克体重/天的剂量降低了亲代的食物消耗量和体重（雄性降低14%至16%，雌性降低4%至5%），增加了肝脏重量，导致肝细胞嗜酸性变以及腺胃黏膜糜烂/溃疡，并使高剂量组F0和F1代母鼠的着床率略有下降。高剂量组F1和F2代幼崽的哺乳体重增加和器官重量降低，性成熟标志延迟。没有证据表明受试化合物对幼崽的性成熟标志有选择性影响。对于生育力和生殖性能、亲代全身毒性和发育毒性，未观察到有害作用的剂量（NOAEL）为450毫克/千克体重/天。
