Tyshko N V, Zhminchenko V M, Selyaskin K E, Pashorina V A, Utembaeva N T, Tutelyan V A
FSBI "Institute of Nutrition" RAMS, Moscow, Russian Federation.
Toxicol Rep. 2014 Jun 11;1:330-340. doi: 10.1016/j.toxrep.2014.05.013. eCollection 2014.
This publication presents the assessment of the impact of genetically modified (GM) LibertyLink maize on reproductive function, prenatal and postnatal progeny development of Wistar rats over three generations. The animals were divided into two groups, which were fed with rodent diet with inclusion of GM LibertyLink ('test' group) and non-GM near-isogenic counterpart ('control' group) maize varieties. The maize was included into the diet at maximum possible level (between 32 and 33%) not causing nutritional imbalance or metabolic disturbance for the experimental animals. Data analysis showed no impact of LibertyLink maize on the animals' fertility: the observed mating efficiency in both groups was within the normal expected range values under the given experiment conditions. The comparison of progeny prenatal development in the generations F0-F2 has not shown any differences between the groups. Analysis of the physical development of the F0-F2 progeny or pups body weight and length progress did not show any abnormalities. The average number of pups per litter in the control and test groups was within the expected range of variations. Therefore, the results should be considered as direct evidence of the lack of any reproductive toxicity of LibertyLink maize (a.k.a. T25 maize).
本出版物介绍了转基因抗除草剂利布灵玉米对三代Wistar大鼠生殖功能、产前和产后子代发育影响的评估。将动物分为两组，分别用含有转基因抗除草剂利布灵玉米（“试验”组）和非转基因近等基因对照玉米品种的啮齿动物饲料喂养。玉米以尽可能高的水平（32%至33%之间）添加到饲料中，且不会对实验动物造成营养失衡或代谢紊乱。数据分析表明，抗除草剂利布灵玉米对动物生育力没有影响：在给定实验条件下，两组观察到的交配效率均在正常预期范围内。F0至F2代子代产前发育的比较未显示两组之间存在任何差异。对F0至F2代子代身体发育或幼崽体重和体长增长的分析未显示任何异常。对照组和试验组每窝幼崽的平均数量在预期变异范围内。因此，这些结果应被视为抗除草剂利布灵玉米（又称T25玉米）不存在任何生殖毒性的直接证据。
