妊娠32周前患有甲状腺毒症的母亲所生婴儿的中枢性甲状腺功能减退症：3例。

Central hypothyroidism in infants who were born to mothers with thyrotoxicosis before 32 weeks' gestation: 3 cases.

作者信息

Higuchi Ryuzo, Miyawaki Masakazu, Kumagai Takeshi, Okutani Takahiro, Shima Yuko, Yoshiyama Megumi, Ban Hiroshi, Yoshikawa Norisige

机构信息

Department of Perinatal Medicine, Wakayama Medical University, 811-1 Kimiidera, Wakayama City 641-0012, Japan.

出版信息

Pediatrics. 2005 May;115(5):e623-5. doi: 10.1542/peds.2004-2128. Epub 2005 Apr 15.

DOI:10.1542/peds.2004-2128

PMID:15833889

Abstract

We describe 3 infants who were born to mothers with Graves' disease and developed central hypothyroidism that persisted for >6 months after birth. Two were preterm infants, and the other was a term infant who was born to a euthyroid mother who had been treated with an antithyroid drug since week 31 of gestation. These cases suggest that passage of thyroid hormones can occur from a thyrotoxic mother to the fetus and that the gestational period earlier than 32 weeks may be the critical time for development of central hypothyroidism.

摘要

我们描述了3例患有格雷夫斯病的母亲所生的婴儿，他们出生后出现中枢性甲状腺功能减退，且在出生后持续超过6个月。其中2例为早产儿，另一例为足月儿，其母亲甲状腺功能正常，自妊娠31周起接受抗甲状腺药物治疗。这些病例表明，甲状腺激素可从甲状腺毒症母亲传递给胎儿，妊娠32周之前的孕期可能是中枢性甲状腺功能减退发生的关键时期。