一名患有格雷夫斯病的母亲所生的早产儿，因垂体抑制导致中枢性甲状腺功能减退和外周甲状腺毒症。

Central hypothyroidism resulting from pituitary suppression and peripheral thyrotoxicosis in a premature infant born to a mother with Graves disease.

作者信息

Hashimoto H, Maruyama H, Koshida R, Okuda N, Sato T

机构信息

Department of Pediatrics, Kanazawa National Hospital, Japan.

出版信息

J Pediatr. 1995 Nov;127(5):809-11. doi: 10.1016/s0022-3476(95)70179-6.

DOI:10.1016/s0022-3476(95)70179-6

PMID:7472842

Abstract

We observed the sequential changes in serum thyroid hormones and thyroid-stimulating hormone receptor antibodies in an infant born at 30 weeks of gestation to a mother with florid Graves disease. Transient central hypothyroidism caused by pituitary suppression was observed after the resolution of peripheral thyrotoxicosis induced by thyroid-stimulating antibody. Central hypothyroidism became overt when the suppression of the pituitary gland after fetal thyrotoxicosis was combined with weak activity of thyroid-stimulating antibody after birth.

摘要

我们观察了一名孕30周出生的婴儿的血清甲状腺激素和促甲状腺激素受体抗体的系列变化，其母亲患有活动性格雷夫斯病。在由促甲状腺素抗体引起的外周甲状腺毒症消退后，观察到垂体抑制导致的短暂性中枢性甲状腺功能减退。当胎儿甲状腺毒症后的垂体抑制与出生后促甲状腺素抗体的弱活性相结合时，中枢性甲状腺功能减退变得明显。