Vollmers H P, Brandlein S
Institute for Pathology, University of Wurzburg, Wurzburg, Germany.
Methods Find Exp Clin Pharmacol. 2005 Apr;27(3):185-91. doi: 10.1358/mf.2005.27.3.890876.
Stress kills and hence should be avoided. On the other hand, stress induction can be used to remove malignant cells by inducing cellular suicide. Natural IgM antibodies act as first-line defense in immune surveillance. These antibodies selectively kill aberrant cells by using different apoptotic stress mechanisms. They can be isolated from patients but also from healthy donors by using the human hybridoma technology. They are components of the innate immunity, and, on the basis of specific screening methods, should also be detectable in any other individual. The three tumor-specific, apoptosis-inducing natural IgM antibodies described in this review are good examples for stress-induced apoptosis and nature's resourceful ways to fight malignant growth.
压力会致命，因此应予以避免。另一方面，可通过诱导细胞自杀来利用压力诱导作用清除恶性细胞。天然IgM抗体在免疫监视中充当一线防御。这些抗体通过使用不同的凋亡应激机制选择性地杀死异常细胞。它们既可以从患者体内分离出来，也可以通过人类杂交瘤技术从健康供体中分离出来。它们是先天免疫的组成部分，并且基于特定的筛选方法，在任何其他个体中也应可检测到。本综述中描述的三种肿瘤特异性、诱导凋亡的天然IgM抗体是压力诱导凋亡以及大自然对抗恶性生长的巧妙方式的很好例证。
