Vollmers H Peter, Brändlein Stephanie
Institute of Pathology, University of Würzburg, Josef-Schneider-Str. 2, D-97080 Würzburg, Germany.
J Autoimmun. 2007 Dec;29(4):295-302. doi: 10.1016/j.jaut.2007.07.013. Epub 2007 Sep 12.
Immunity is not only responsible for recognition and elimination of infectious particles, but also for removal of cellular waste, modified self structures and transformed cells. Innate or natural immunity acts as a first line defense and is also the link to acquired immunity and memory. A striking phenomenon of immunity against malignant cells is that neither in animals nor in humans affinity-maturated tumor-specific IgG antibodies have been detected so far. All tumor-specific isolated antibodies were germ-line coded natural IgM antibodies. It's also a fact that these IgM's preferentially bind to carbohydrate epitopes on post-transcriptionally modified surface receptors and that they all induce a cancer-specific apoptosis, by triggering the intrinsic apoptotic pathway. From an evolutionary point of view, this makes sense because cancer cells are not infectious, so there is no need for memory. Natural IgMs bind to conservative structures because they are coded by a limited set of genes and they use apoptosis, the "clean" way of killing, to avoid inflammatory processes.
免疫不仅负责识别和清除感染性颗粒，还负责清除细胞废物、修饰的自身结构和转化细胞。先天免疫或天然免疫作为第一道防线，也是与获得性免疫和记忆的联系。针对恶性细胞免疫的一个显著现象是，迄今为止，在动物和人类中均未检测到亲和力成熟的肿瘤特异性IgG抗体。所有分离出的肿瘤特异性抗体均为种系编码的天然IgM抗体。同样事实是，这些IgM优先结合转录后修饰的表面受体上的碳水化合物表位，并且它们均通过触发内在凋亡途径诱导癌症特异性凋亡。从进化的角度来看，这是有道理的，因为癌细胞不具传染性，所以无需记忆。天然IgM结合保守结构，因为它们由一组有限的基因编码，并且它们采用凋亡这种“清洁”的杀伤方式来避免炎症过程。
