Bender Florian, Länge Kerstin, Barié Nicole, Kondoh Jun, Rapp Michael
Forschungszentrum Karlsruhe, Institute for Instrumental Analysis, Postfach 3640, 76021 Karlsruhe, Germany.
Langmuir. 2004 Mar 16;20(6):2315-9. doi: 10.1021/la035674c.
The Love-wave sensor is an acoustic sensing device which is particularly suitable for sensing in a liquid environment. The superior characteristics of the device are achieved by the use of an acoustic waveguide, consisting of a thin layer deposited on the surface of the substrate material. The exact thickness and material properties of the layer will not only determine sensitivity and sensing performance of the resulting device but can also be adjusted to generate higher-order Love modes. Thus, to obtain a sensing device with the desired specifications, precise control over the process of waveguide deposition is required. This has been realized by implementation of a vapor deposition polymerization system where the transmission curve (amplitude vs frequency) of one of the sensing devices is continuously monitored during deposition. As soon as the desired device specifications are reached, the deposition can be interrupted immediately. From the recorded transmission curves, information about the sensitivity of the device can be deduced, and the formation of higher-order Love modes can be visualized. The system has been used to produce biosensors based on various Love modes. It is shown that sensors operated on higher-order Love modes have a high mass sensitivity which, together with their excellent shielding properties, makes them advantageous for biosensing in conducting buffer solutions.
洛夫波传感器是一种声学传感装置，特别适用于在液体环境中进行传感。该装置的卓越特性是通过使用一种声学波导实现的，这种波导由沉积在基底材料表面的薄层组成。该层的确切厚度和材料特性不仅会决定最终装置的灵敏度和传感性能，还可以进行调整以产生高阶洛夫模式。因此，为了获得具有所需规格的传感装置，需要对波导沉积过程进行精确控制。这是通过实施气相沉积聚合系统实现的，在沉积过程中，其中一个传感装置的传输曲线（幅度与频率）会被持续监测。一旦达到所需的装置规格，沉积即可立即中断。从记录的传输曲线中，可以推断出有关该装置灵敏度的信息，并且可以直观显示高阶洛夫模式的形成。该系统已被用于生产基于各种洛夫模式的生物传感器。结果表明，基于高阶洛夫模式运行的传感器具有很高的质量灵敏度，再加上其出色的屏蔽特性，使其在导电缓冲溶液中的生物传感方面具有优势。
