Cai Zhu-Hua, He Yuan-Li, Peng Dong-Xian
Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Di Yi Jun Yi Da Xue Xue Bao. 2005 Apr;25(4):464-5.
To investigate the role of serum epithelial neutrophil-activating peptide-78 (ENA-78) in the pathogenesis of endometriosis.
Serum concentrations of ENA-78 were measured by means of enzyme-linked immunosorbent assay (ELISA) in 42 patients with endometriosis (20 in stages I and II and 22 in stages III and IV) in comparison with 25 women without endometriosis (control group).
Serum concentrations of ENA-78 were significantly higher in endometriosis group than in the control group (2.97+/-1.91 ng/ml vs 0.72+/-0.24 ng/ml, P>0.001), and ENA-78 levels in stages III and IV were significantly higher than those in stages I and II (4.48+/-1.25 ng/ml vs 1.30+/-0.74 ng/ml, P>0.001). Significant difference in ENA-78 levels between follicular phase and luteal phase was found in neither of the groups.
Patients with endometriosis have elevated serum ENA-78 levels, which might be a pathogenic factor of endometriosis.
探讨血清上皮中性粒细胞激活肽-78（ENA-78）在子宫内膜异位症发病机制中的作用。
采用酶联免疫吸附测定法（ELISA）检测42例子宫内膜异位症患者（I、II期20例，III、IV期22例）血清ENA-78浓度，并与25例无子宫内膜异位症的女性（对照组）进行比较。
子宫内膜异位症组血清ENA-78浓度显著高于对照组（2.97±1.91 ng/ml对0.72±0.24 ng/ml，P>0.001），III、IV期ENA-78水平显著高于I、II期（4.48±1.25 ng/ml对1.30±0.74 ng/ml，P>0.001）。两组卵泡期和黄体期ENA-78水平均无显著差异。
子宫内膜异位症患者血清ENA-78水平升高，这可能是子宫内膜异位症的致病因素。
