Narang Sanjeev, Kanungo Namrata, Jain Ravi
Department of Pathology, M.G.M Medical College, A.B. Road, Indore, PIN 452001 M.P. India.
Indian J Surg. 2014 Apr;76(2):104-10. doi: 10.1007/s12262-012-0621-6. Epub 2012 Jul 4.
Squamous cell carcinoma, which is a malignant tumor of the squamous epithelium, has been a major cause of morbidity and mortality worldwide. It is a major health problem across the world and among the most common cancers seen in both Indian men and women as can be gauged from the records of the National Cancer Registry Programme. This study was undertaken to analyze the spectrum of squamous cell carcinoma cases presenting at M.Y. Hospital, Indore, during 2 years between 2007 and 2008, to understand the morphological patterns of squamous cell carcinoma lesions and classify them into morphological categories given by International Classification of Diseases for Oncology (ICD-O, third edition), to analyze the anatomical site distribution pattern of squamous cell carcinoma lesions and categorize them in topographical classes given by ICD-O. Over a 2-year period, 959 cases were retrieved from the files of histopathology laboratory, department of pathology, M.G.M. Medical College, Indore. Out of total 959 cases, the maximum cases-290 (30.24 %)-of squamous cell carcinoma were found between the fourth and fifth decades of life. The frequency of squamous cell carcinoma in patients older than 30 years was 96.35 %, while in cases of less than 30 years, it was 03.65 %. Most of the reported cases of squamous cell carcinoma included invasive types (i.e., 94.3 %). Cases with distant metastasis constituted 4.7 %, while only 1 % were noninvasive or in situ. The frequency of squamous cell carcinoma presenting at our institution was highest among those involving the lip, oral cavity, and pharynx (56.50 %), followed by those involving female genital organs (30.24 %). The respective involvement of skin, digestive organs, and respiratory systems was 4.70, 3.86, and 2.40 % in decreasing order of frequency. Frequency was least (1.05 %) among the cases reported to show metastatic deposits of squamous cell carcinoma in lymph nodes. Regarding the topographical spectrum, the maximum number of cases (26.07 %) of squamous cell carcinoma encountered belonged to ICD-O category C-53 (i.e., cervix). Among the morphological categories, the most frequently encountered was that of squamous cell carcinoma, keratinizing (35.2 %).
鳞状细胞癌是一种鳞状上皮的恶性肿瘤，一直是全球发病和死亡的主要原因。它是一个全球性的重大健康问题，从国家癌症登记计划的记录可以看出，它是印度男性和女性中最常见的癌症之一。本研究旨在分析2007年至2008年期间在印多尔M.Y.医院就诊的鳞状细胞癌病例谱，了解鳞状细胞癌病变的形态学模式，并根据国际肿瘤疾病分类（ICD-O，第三版）给出的形态学类别进行分类，分析鳞状细胞癌病变的解剖部位分布模式，并根据ICD-O给出的地形学类别进行分类。在两年时间里，从印多尔M.G.M.医学院病理学系组织病理学实验室的档案中检索到959例病例。在总共959例病例中，鳞状细胞癌病例最多，为290例（30.24%），发生在40至50岁之间。30岁以上患者的鳞状细胞癌发病率为96.35%，而30岁以下患者的发病率为3.65%。报告的大多数鳞状细胞癌病例为浸润性类型（即94.3%）。远处转移病例占4.7%，而非浸润性或原位病例仅占1%。在我们机构就诊的鳞状细胞癌发病率在涉及唇部、口腔和咽部的病例中最高（56.5%），其次是涉及女性生殖器官的病例（30.24%）。皮肤、消化器官和呼吸系统的受累率分别为4.70%、3.86%和2.40%，频率依次降低。在报告显示鳞状细胞癌在淋巴结有转移灶的病例中，频率最低（1.05%）。关于地形学谱，遇到的鳞状细胞癌病例中数量最多的（26.07%）属于ICD-O类别C-53（即子宫颈）。在形态学类别中，最常遇到的是角化性鳞状细胞癌（35.2%）。
