Baksu Alparslan, Ozkan Arzu, Goker Nimet, Baksu Başak, Uluocak Aygul
1st Obstetrics and Gynecology Clinic, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.
Am J Perinatol. 2005 Apr;22(3):161-4. doi: 10.1055/s-2005-864853.
The objective of this study was to evaluate the change in maternal serum leptin levels in preeclampsia and to study the relationship between maternal serum leptin and thyroid-stimulating hormone (TSH), body mass index (BMI), newborn weight, and proteinuria. Eighty-five pregnant women were included in this prospective study, of whom 50 were preeclamptic and 35 were normotensive. Maternal serum leptin levels were measured by the radioimmunoassay technique and TSH levels were measured by the electrochemiluminescence immunoassay method. The maternal serum leptin levels of preeclamptic and normotensive pregnant women were compared. In each group, the relationship between maternal serum leptin levels and TSH levels, BMI, newborn weight, and proteinuria was evaluated. The maternal serum leptin level was significantly higher in the preeclamptics than in the normotensive pregnant women. In the preeclamptic group, there was a strong positive correlation between maternal serum leptin levels and BMI (r =- 0.80; p < 0.001), a very weak positive correlation between maternal serum leptin levels and proteinuria (r = 0.305; p < 0.05), and a very weak inverse correlation between maternal serum leptin levels and birth weight (r = -0.377; p < 0.01). In the same group, there was no correlation between maternal serum leptin and serum TSH levels (r = 0.22; p > 0.05; Pearson correlation test). Leptin may be involved in the pathology of preeclampsia, and elevated maternal serum leptin levels may be a marker for the early stages of preeclampsia in pregnant women.
本研究的目的是评估子痫前期孕妇血清瘦素水平的变化，并研究孕妇血清瘦素与促甲状腺激素（TSH）、体重指数（BMI）、新生儿体重和蛋白尿之间的关系。85名孕妇被纳入这项前瞻性研究，其中50名为子痫前期患者，35名血压正常。采用放射免疫测定技术测量孕妇血清瘦素水平，采用电化学发光免疫分析法测量TSH水平。比较子痫前期孕妇和血压正常孕妇的血清瘦素水平。在每组中，评估孕妇血清瘦素水平与TSH水平、BMI、新生儿体重和蛋白尿之间的关系。子痫前期患者的孕妇血清瘦素水平显著高于血压正常的孕妇。在子痫前期组中，孕妇血清瘦素水平与BMI之间存在强正相关（r = -0.80；p < 0.001），与蛋白尿之间存在非常弱的正相关（r = 0.305；p < 0.05），与出生体重之间存在非常弱的负相关（r = -0.377；p < 0.01）。在同一组中，孕妇血清瘦素与血清TSH水平之间无相关性（r = 0.22；p > 0.05；Pearson相关检验）。瘦素可能参与子痫前期的病理过程，孕妇血清瘦素水平升高可能是孕妇子痫前期早期的一个标志物。
