Rijneveld Anita W, de Vos Alex F, Florquin Sandrine, Verbeek J Sjef, van der Poll Tom
Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
J Infect Dis. 2005 May 15;191(10):1755-60. doi: 10.1086/429633. Epub 2005 Apr 6.
Expression of CD11b is enhanced on neutrophils recruited to the lungs during bacterial pneumonia. To determine the role that CD11b plays in pneumonia, CD11b gene-deficient (CD11b(-/-)) mice and normal wild-type (wt) mice were intranasally infected with Streptococcus pneumoniae. CD11b(-/-) mice had an enhanced outgrowth of pneumococci in the lungs and an increased dissemination of the infection, which could be reproduced by treatment of wt mice with an anti-CD11b antibody. This reduced resistance was associated with higher neutrophil counts in bronchoalveolar lavage fluid and lung tissue and an exaggerated lung inflammatory response. CD11b is important for an effective defense against S. pneumoniae pneumonia but not for recruitment of neutrophils.
在细菌性肺炎期间，募集到肺部的中性粒细胞上CD11b的表达增强。为了确定CD11b在肺炎中所起的作用，将CD11b基因缺陷（CD11b(-/-)）小鼠和正常野生型（wt）小鼠经鼻感染肺炎链球菌。CD11b(-/-)小鼠肺部肺炎球菌的生长增强且感染播散增加，用抗CD11b抗体处理wt小鼠可重现这一现象。这种抵抗力降低与支气管肺泡灌洗液和肺组织中更高的中性粒细胞计数以及过度的肺部炎症反应相关。CD11b对于有效抵御肺炎链球菌肺炎很重要，但对中性粒细胞的募集并不重要。
