García A J, Reyes C D
Woodruff School of Mechanical Engineering, Petit Institute for Bioengineering and Bioscience, 315 Ferst Drive, 2314 Petit Biotechnology Building, Atlanta, GA 30332-0363, USA.
J Dent Res. 2005 May;84(5):407-13. doi: 10.1177/154405910508400502.
Binding of integrin adhesion receptors to extracellular matrix components, such as fibronectin and type I collagen, activates signaling pathways directing osteoblast survival, cell-cycle progression, gene expression, and matrix mineralization. Biomimetic strategies exploit these adhesive interactions to engineer bio-inspired surfaces that promote osteoblast adhesion and differentiation, bone formation, and osseointegration. These emerging initiatives focus on directing integrin binding through presentation of bio-adhesive motifs derived from extracellular matrices. These biomolecular approaches provide promising strategies for the development of biologically active implants and grafting substrates for enhanced bone repair.
整合素粘附受体与细胞外基质成分（如纤连蛋白和I型胶原蛋白）的结合，激活了指导成骨细胞存活、细胞周期进程、基因表达和基质矿化的信号通路。仿生策略利用这些粘附相互作用来设计具有生物启发性的表面，以促进成骨细胞的粘附和分化、骨形成以及骨整合。这些新兴举措专注于通过呈现源自细胞外基质的生物粘附基序来引导整合素结合。这些生物分子方法为开发用于增强骨修复的生物活性植入物和移植基质提供了有前景的策略。
