无临床腺病毒相关呼吸道疾病患者下呼吸道中腺病毒的定量分析。

Quantification of adenovirus in the lower respiratory tract of patients without clinical adenovirus-related respiratory disease.

作者信息

Leung Anskar Yu-Hung, Chan Maggie, Cheng Vincent Chi-Chung, Yuen Kwok-Yung, Kwong Yok-Lam

机构信息

Department of Medicine, University of Hong Kong, Hong Kong.

出版信息

Clin Infect Dis. 2005 May 15;40(10):1541-4. doi: 10.1086/429627. Epub 2005 Apr 4.

DOI:10.1086/429627

PMID:15844080

Abstract

Adenovirus in bronchoalveolar lavage fluid samples from 50 patients without adenovirus-related illness was quantified. In 49 patients, adenovirus was found (median load, 3.3 x 10(3) copies/microg of DNA). The adenovirus load was inversely related to lymphocyte count (Pearson correlation coefficient r = -0.311; P = .03) and was significantly greater in immunosuppressed patients than in immunocompetent patients (5.1 x 10(3) vs. 2.0 x 10(3) copies/microg of DNA; P = .028).

摘要

对50例无腺病毒相关疾病患者的支气管肺泡灌洗液样本中的腺病毒进行了定量分析。在49例患者中检测到了腺病毒（中位载量为3.3×10³拷贝/微克DNA）。腺病毒载量与淋巴细胞计数呈负相关（Pearson相关系数r = -0.311；P = 0.03），免疫抑制患者的腺病毒载量显著高于免疫功能正常的患者（5.1×10³拷贝/微克DNA对2.0×10³拷贝/微克DNA；P = 0.028）。