Groves Jay T
Department of Chemistry, University of California Berkeley, USA.
Angew Chem Int Ed Engl. 2005 Jun 6;44(23):3524-38. doi: 10.1002/anie.200461014.
Surfaces create an environment in which multiple forces conspire together to yield a wealth of complex chemical processes. This is especially true of cell membranes, whose fluidity and flexibility enables responsive feedback with surface chemical interactions in ways not generally seen with inorganic materials. Spatial pattern formation of cell-surface proteins at intermembrane junctions provides many beautiful examples of these phenomena, and is also emerging as a functional aspect of intercellular signaling. Correspondingly, the study of interactions of cell-membrane surfaces is attracting significant attention from cell biologists and physical chemists alike. This convergence is fueled be recent, exquisite observations of protein pattern formation events within living immunological synapses along with parallel advances in membrane reconstitution, manipulation, and imaging technologies.
表面创造了一个环境，在这个环境中多种力量共同作用，产生了大量复杂的化学过程。细胞膜尤其如此，其流动性和灵活性能够以无机材料通常不具备的方式与表面化学相互作用产生响应反馈。膜间连接处细胞表面蛋白的空间模式形成提供了许多这些现象的美妙例子，并且也正在成为细胞间信号传导的一个功能方面。相应地，细胞膜表面相互作用的研究正吸引着细胞生物学家和物理化学家的极大关注。这种融合是由最近对活的免疫突触内蛋白质模式形成事件的精确观察以及膜重构、操作和成像技术的平行进展推动的。
