Taha Ali S, Faccenda Elena, Angerson Wilson J, Balsitis Margaret, Kelly Rodney W
Crosshouse Hospital, Kilmarnock, Scotland, United Kingdom.
Dig Dis Sci. 2005 Apr;50(4):791-5. doi: 10.1007/s10620-005-2575-z.
As infection influences the pathogenesis and presentation of celiac disease, we investigated the expression of natural antibiotics in this condition. Twenty-three adults were prospectively studied: 10 controls and 13 subjects with untreated celiac disease. Distal duodenal biopsies were taken at baseline and after 6 months of a gluten-free diet and assessed for the expression of natural antibiotics. Epithelial human beta-defensin 1 in subjects with celiac disease had a median of 0.02 unit at baseline, compared with 0.34 unit in controls (P < 0.001). It correlated negatively with the degree of villous atrophy (r = -0.64, P = 0.019) and rose to 0.04 unit on the gluten-free diet (P = 0.035 vs. baseline, P < 0.001 vs. controls). The expression of other antibiotics was unchanged. The expression of epithelial natural antibiotics is limited in celiac disease.
由于感染会影响乳糜泻的发病机制和临床表现，我们研究了这种情况下天然抗生素的表达。对23名成年人进行了前瞻性研究：10名对照者和13名未经治疗的乳糜泻患者。在基线时以及无麸质饮食6个月后采集十二指肠远端活检组织，并评估天然抗生素的表达。乳糜泻患者上皮人β-防御素1在基线时的中位数为0.02单位，而对照者为0.34单位（P < 0.001）。它与绒毛萎缩程度呈负相关（r = -0.64，P = 0.019），在无麸质饮食时升至0.04单位（与基线相比P = 0.035，与对照者相比P < 0.001）。其他抗生素的表达没有变化。乳糜泻中上皮天然抗生素的表达受限。
