Coleman Robert S, Gurrala Srinivas Reddy
Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
Org Lett. 2005 Apr 28;7(9):1849-52. doi: 10.1021/ol050476t.
[structure: see text] Asymmetric total syntheses of the dibenzocyclooctadiene lignans interiotherin A and angeloylgomisin R are reported. The syntheses were based on an atropdiastereoselective, copper-promoted biaryl coupling reaction, a diastereoselective hydroboration/Suzuki-Miyaura coupling reaction sequence, and an asymmetric boron-mediated tiglylation of an aryl aldehyde precursor.
[结构：见正文] 报道了二苯并环辛二烯木脂素interiotherin A和当归酰戈米辛R的不对称全合成。合成基于非对映选择性、铜促进的联芳基偶联反应、非对映选择性硼氢化/铃木-宫浦偶联反应序列以及芳醛前体的不对称硼介导的巴豆酰化反应。
