State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
J Nat Prod. 2012 Feb 24;75(2):249-56. doi: 10.1021/np200937h. Epub 2012 Feb 13.
Eleven new dibenzocyclooctadiene lignans, polysperlignans A-K (1-11), and eight known analogues (12-19) were isolated from the stems of Kadsura polysperma. Their structures and absolute configurations were established using a combination of MS, NMR, CD, and single-crystal X-ray diffraction techniques. Selected compounds were evaluated for activity against β-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, and 1, 2, 4, 5, 13, and 16 showed statistically significant neuroprotective effects in these in vitro assays.
从多穗柯（Kadsura polysperma）茎中分离得到 11 个新的二苯并环辛二烯木脂素、多穗柯新木脂素 A-K（1-11）和 8 个已知类似物（12-19）。通过 MS、NMR、CD 和单晶 X 射线衍射技术的组合，确定了它们的结构和绝对构型。选择了一些化合物，对其在 PC12 细胞中对β-淀粉样蛋白或过氧化氢诱导的神经毒性的活性进行了评估，在这些体外试验中，化合物 1、2、4、5、13 和 16 显示出统计学上显著的神经保护作用。
