黑老虎的化合物及其相关抗HIV活性。

Compounds from Kadsura heteroclita and related anti-HIV activity.

作者信息

Pu Jian-Xin, Yang Liu-Meng, Xiao Wei-Lie, Li Rong-Tao, Lei Chun, Gao Xue-Mei, Huang Sheng-Xiong, Li Sheng-Hong, Zheng Yong-Tang, Huang Hao, Sun Han-Dong

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.

出版信息

Phytochemistry. 2008 Mar;69(5):1266-72. doi: 10.1016/j.phytochem.2007.11.019. Epub 2008 Jan 22.

DOI:10.1016/j.phytochem.2007.11.019

PMID:18207206

Abstract

Phytochemical investigation of the stems of Kadsura heteroclita led to isolation of 16 compounds, including the triterpenoid named longipedlactone J (2), and two dibenzocyclooctadiene type lignans named heteroclitin I and J (3, 4). Compounds 8-10, 14, and 15 were weakly active as anti-HIV agents, whereas compounds 6 and 12 exhibited moderate anti-HIV activity with EC50 values of 1.6 microg/mL, and 1.4 microg/mL, therapeutic index (TI) values of 52.9, and 65.9, respectively. Their structures were established by spectroscopic methods, including application of 2D NMR techniques and CD spectra.

摘要

对异型南五味子茎进行植物化学研究，分离出16种化合物，包括三萜类化合物长梗南五味子内酯J（2），以及两种二苯并环辛二烯型木脂素异型南五味子素I和J（3,4）。化合物8 - 10、14和15作为抗HIV药物活性较弱，而化合物6和12表现出中等抗HIV活性，其半数有效浓度（EC50）值分别为1.6微克/毫升和1.4微克/毫升，治疗指数（TI）值分别为52.9和65.9。通过光谱方法，包括二维核磁共振（2D NMR）技术和圆二色光谱（CD）确定了它们的结构。