Silchenko Alexandra S, Stonik Valentin A, Avilov Sergey A, Kalinin Vladimir I, Kalinovsky Anatoly I, Zaharenko Alexandr M, Smirnov Alexey V, Mollo Ernesto, Cimino Guido
Pacific Institute of Bioorganic Chemistry, Far East Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russian Federation.
J Nat Prod. 2005 Apr;68(4):564-7. doi: 10.1021/np049631n.
Triterpene glycosides of three species of the Mediterranean sea cucumbers Holothuria polii, Holothuria tubulosa, and Holothuria sp. were studied. Three new monosulfated biosides, holothurins B(2) (1), B(3) (2), and B(4) (3), along with the previously known holothurins A (4) and B (5) were isolated from the sea cucumber H. polii. Triterpene glycosides belonging to holothurin A and B groups were found in H. tubulosa, while only one individual glycoside, holothurin A (4), was isolated from Holothuria sp. Structures of new substances were elucidated on the basis of spectral data (2D NMR and MS). The significance of holothurins as chemotaxonomic markers of the animals belonging to the genus Holothuria and taxonomic status of some representatives of the holothurians studied are discussed.
对三种地中海海参，即波利氏海参（Holothuria polii）、管足海参（Holothuria tubulosa）和一种未明确的海参（Holothuria sp.）的三萜糖苷进行了研究。从波利氏海参中分离出三种新的单硫酸化生物苷，即海参毒素B(2)（1）、B(3)（2）和B(4)（3），以及先前已知的海参毒素A（4）和B（5）。在管足海参中发现了属于海参毒素A和B组的三萜糖苷，而从一种未明确的海参中仅分离出一种单一糖苷，即海参毒素A（4）。根据光谱数据（二维核磁共振和质谱）阐明了新物质的结构。讨论了海参毒素作为海参属动物化学分类标记的意义以及所研究的一些海参代表的分类地位。
