希拉皂苷A和B，两种从希氏海参（Holothuria hilla Lesson）中分离得到的新型细胞毒性三萜糖苷。

Hillasides A and B, two new cytotoxic triterpene glycosides from the sea cucumber Holothuria hilla Lesson.

作者信息

Wu Jun, Yi Yang-Hua, Tang Hai-Feng, Wu Hou-Ming, Zhou Zhen-Rong

机构信息

College of Pharmacy, Research Center for Marine Drugs, Second Military Medical University, Shanghai, China.

出版信息

J Asian Nat Prod Res. 2007 Sep-Dec;9(6-8):609-15. doi: 10.1080/10286020600882676.

DOI:10.1080/10286020600882676

PMID:17943555

Abstract

Two new triterpene glycosides, hillasides A (1) and B (2), were isolated from the sea cucumber H. hilla Lesson, together with one known glycoside holothuria B (3). Their structures were deduced by extensive spectral analysis and chemical evidences. The presence of conjugated double bonds [22E,24-diene] in the aglycone of 1 is a rare structural feature among sea cucumber glycosides. The two glycosides showed significant cytotoxicity against eight human tumour cell lines (A-549, MCF-7, IA9, CAKI-1, PC-3, KB, KB-VIN and HCT-8) with IC(50) in the range of 0.1-3.8 microg/ml.

摘要

从海参H. hilla Lesson中分离出两种新的三萜糖苷，即希拉苷A（1）和希拉苷B（2），以及一种已知的糖苷海参苷B（3）。通过广泛的光谱分析和化学证据推断出它们的结构。1的苷元中存在共轭双键[22E,24 - 二烯]，这在海参糖苷中是一种罕见的结构特征。这两种糖苷对八种人类肿瘤细胞系（A - 549、MCF - 7、IA9、CAKI - 1、PC - 3、KB、KB - VIN和HCT - 8）显示出显著的细胞毒性，半数抑制浓度（IC50）在0.1 - 3.8微克/毫升范围内。