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海参糖苷：化学结构、产生物种和重要的生物学特性。

Sea Cucumber Glycosides: Chemical Structures, Producing Species and Important Biological Properties.

机构信息

School of Science and Technology, Bangladesh Open University, Board Bazar, Gazipur 1705, Bangladesh.

Marine Natural Products Laboratory, Korea Institute of Ocean Science and Technology, 787 Haeanro, Ansan 427-744, Korea.

出版信息

Mar Drugs. 2017 Oct 17;15(10):317. doi: 10.3390/md15100317.

DOI:10.3390/md15100317
PMID:29039760
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5666425/
Abstract

Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holostane and nonholostane depending on the presence or absence of a specific structural unit γ(18,20)-lactone in the aglycone. Triterpene glycosides contain a carbohydrate chain up to six monosaccharide units mainly consisting of d-xylose, 3-O-methy-d-xylose, d-glucose, 3-O-methyl-d-glucose, and d-quinovose. Cytotoxicity is the common biological property of triterpene glycosides isolated from sea cucumbers. Besides cytotoxicity, triterpene glycosides also exhibit antifungal, antiviral and hemolytic activities. This review updates and summarizes our understanding on diverse chemical structures of triterpene glycosides from various species of sea cucumbers and their important biological activities. Mechanisms of action and structural-activity relationships (SARs) of sea cucumber glycosides are also discussed briefly.

摘要

海参属于棘皮动物，在中国和其他亚洲国家传统上被用作滋补食品。它们产生丰富的生物活性三萜糖苷。从各种海参物种中分离和鉴定出超过 300 种三萜糖苷，根据糖苷元中是否存在特定的结构单元γ(18,20)-内酯，将其分为全甾烷和非全甾烷。三萜糖苷含有长达六个单糖单元的碳水化合物链，主要由 d-木糖、3-O-甲基-d-木糖、d-葡萄糖、3-O-甲基-d-葡萄糖和 d-奎诺糖组成。细胞毒性是从海参中分离出的三萜糖苷的共同生物学特性。除了细胞毒性外，三萜糖苷还具有抗真菌、抗病毒和溶血活性。本综述更新并总结了我们对各种海参物种三萜糖苷的不同化学结构及其重要生物学活性的认识。还简要讨论了海参糖苷的作用机制和构效关系 (SAR)。

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