通过铜催化的与芳基卤化物直接偶联实现2'-脱氧腺苷的N6-芳基化反应。
N6-Arylation of 2'-deoxyadenosine via copper-catalyzed direct coupling with aryl halides.
作者信息
Ran Chongzhao, Dai Qing, Harvey Ronald G
机构信息
Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA.
出版信息
J Org Chem. 2005 Apr 29;70(9):3724-6. doi: 10.1021/jo040284w.
PMID:15845015
Abstract
[reaction: see text] A general method for efficient N(6)-arylation of 2'-deoxyadenosine via copper-catalyzed direct coupling with aryl iodides and bromides is described. The method is useful for aryl halides with either electron-donating or electron-withdrawing groups.
摘要
[反应：见正文] 描述了一种通过铜催化2'-脱氧腺苷与芳基碘化物和溴化物直接偶联实现高效N(6)-芳基化的通用方法。该方法适用于带有供电子基团或吸电子基团的芳基卤化物。
Zotero 插件