Altman Ryan A, Buchwald Stephen L
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, 02139, USA.
Org Lett. 2006 Jun 22;8(13):2779-82. doi: 10.1021/ol0608505.
[reaction: see text] 4,7-Dimethoxy-1,10-phenanthroline (L) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazole with aryl iodides and bromides under mild conditions. A variety of hindered and functionalized imidazoles and aryl halides were transformed in good to excellent yields.
[反应：见正文] 发现4,7-二甲氧基-1,10-菲咯啉（L）是一种有效的配体，可在温和条件下用于铜催化的咪唑与芳基碘化物和溴化物的N-芳基化反应。多种受阻和官能化的咪唑及芳基卤化物能以良好至优异的产率进行转化。
