Lagarde Emmanuel, Chastang Jean-François, Lafont Sylviane, Coeuret-Pellicer Mireille, Chiron Mireille
INSERM U88, 14 rue du Val d'Osne, 94410 Saint Maurice, France.
J Clin Epidemiol. 2005 May;58(5):524-31. doi: 10.1016/j.jclinepi.2004.09.008.
To assess the influence of medical conditions on road traffic accidents among a cohort of middle-aged workers and pensioners.
A longitudinal study of 13,548 participants from a cohort study of French workers. Follow-up data covered the 1989-2000 period. Adjusted hazards ratios (HR(adj)) for serious accidents were computed by Cox's proportional hazards regression with time-dependent covariates adjusted for age, occupation, annual mileage in 2001, alcohol consumption, and number of reported health problems.
Men who reported treated dental or gingival problems (HR(adj)=8.57, 95% confidence interval CI=2.70-27.2) and women who reported treated renal colic or kidney stones (HR(adj)=9.71, 95% CI=2.40-39.3) were much more likely to have a serious traffic accident. Treated glaucoma, hiatal hernia or gastric ulcers, and diabetes among women and treated cataract among men were also found to be associated with the risk of serious traffic accidents.
This study raises the hypothesis that pain and pain treatment (singly or in combination) could increase the risk of road traffic accident and confirms that medical conditions traditionally found to be associated with traffic accident involvement of older drivers are also risk factors for middle-aged drivers.
评估一系列疾病对一群中年工人和退休人员道路交通事故的影响。
对来自法国工人队列研究的13548名参与者进行的纵向研究。随访数据涵盖1989 - 2000年期间。通过Cox比例风险回归计算严重事故的调整风险比（HR(adj)），并对年龄、职业、2001年年行驶里程、饮酒量和报告的健康问题数量等随时间变化的协变量进行调整。
报告接受过牙科或牙龈问题治疗的男性（HR(adj)=8.57，95%置信区间CI=2.70 - 27.2）以及报告接受过肾绞痛或肾结石治疗的女性（HR(adj)=9.71，95% CI=2.40 - 39.3）发生严重交通事故的可能性要高得多。还发现女性中的青光眼、食管裂孔疝或胃溃疡以及糖尿病，男性中的白内障治疗也与严重交通事故风险相关。
本研究提出疼痛和疼痛治疗（单独或联合）可能增加道路交通事故风险的假设，并证实传统上认为与老年驾驶员交通事故有关的疾病也是中年驾驶员的风险因素。
