Santambrogio Luisa G, Mencherini Simonetta, Fuardo Marinella, Caramella Flavia, Braschi Antonio
*Department of Anesthesia and Intensive Care, IRCCS Policlinico San Matteo, Pavia, and †Department of Anesthesia and Reanimation, University of Pavia, Pavia, Italy.
Anesth Analg. 2005 May;100(5):1263-1266. doi: 10.1213/01.ANE.0000149327.23267.6B.
Brugada syndrome is characterized by a distinctive electrocardiographic pattern (right bundle branch block and ST segment elevation in precordial leads) and a high risk of cardiac arrest for malignant dysrhythmia. The genetic basis is a molecular defect of the cardiac sodium channel and the pattern of inheritance is autosomal dominant. Many factors during general anesthesia (medications, bradycardia, temperature changes) could precipitate malignant dysrhythmia in these patients. Because criteria to identify the surgical patient at high risk for developing malignant dysrhythmia are lacking, we can only speculate about the available studies on nonsurgical patients. We describe four patients during general anesthesia and propose intraoperative and postoperative monitoring (the first 36 h).
Brugada综合征的特征是具有独特的心电图模式（右束支传导阻滞和胸前导联ST段抬高）以及因恶性心律失常导致心脏骤停的高风险。其遗传基础是心脏钠通道的分子缺陷，遗传模式为常染色体显性遗传。全身麻醉期间的许多因素（药物、心动过缓、体温变化）都可能促使这些患者发生恶性心律失常。由于缺乏识别手术患者发生恶性心律失常高风险的标准，我们只能推测针对非手术患者的现有研究情况。我们描述了4例全身麻醉期间的患者，并建议进行术中及术后监测（最初36小时）。
