血浆中BK病毒载量：同种异体造血细胞移植受者出血性膀胱炎相关性的证据
BK DNA viral load in plasma: evidence for an association with hemorrhagic cystitis in allogeneic hematopoietic cell transplant recipients.
作者信息
Erard Veronique, Kim Hyung Woo, Corey Lawrence, Limaye Ajit, Huang Meei-Li, Myerson David, Davis Chris, Boeckh Michael
机构信息
Division of Clinical Research, Fred Hutchinson Cancer Research Center, Program in Infectious Diseases, 1100 Fairview Ave North D3-100, PO Box 19024, Seattle, WA 98109-1024, USA.
出版信息
Blood. 2005 Aug 1;106(3):1130-2. doi: 10.1182/blood-2004-12-4988. Epub 2005 Apr 21.
Abstract
We performed a case-control study to determine the association of BK plasma viremia with hemorrhagic cystitis (HC) in hematopoietic cell transplant (HCT) recipients. Thirty cases of HC (14 of which occurred after platelet engraftment with documented BK viruria [BK-HC]) were compared with matched controls. Weekly plasma samples were tested for BK virus DNA by polymerase chain reaction (PCR). BK viremia detected before or during the disease was independently associated with HC (adjusted odds ratio = 30, P < .001); BK viremia was even important before clinical symptoms of HC occurred (odds ratio = 11, P < .001). Cases of HC and BK-HC had a significantly higher peak of BK plasma viral load than controls. BK virus was detected by in situ hybridization in bladder biopsies of 2 cases with severe HC and long-lasting BK viremia. BK virus seems to play a role in the development of HC and quantitative detection of BK DNA in plasma appears to be a marker of BK virus disease in HCT recipients.
摘要
我们开展了一项病例对照研究，以确定造血细胞移植（HCT）受者中BK病毒血症与出血性膀胱炎（HC）之间的关联。将30例HC患者（其中14例在血小板植入后发生，并记录有BK病毒尿症[BK-HC]）与匹配的对照组进行比较。每周采集血浆样本，通过聚合酶链反应（PCR）检测BK病毒DNA。疾病发生前或期间检测到的BK病毒血症与HC独立相关（校正比值比=30，P<.001）；在HC临床症状出现之前，BK病毒血症就已具有重要意义（比值比=11，P<.001）。HC和BK-HC患者的BK血浆病毒载量峰值显著高于对照组。在2例患有严重HC且BK病毒血症持续时间较长的患者的膀胱活检组织中，通过原位杂交检测到了BK病毒。BK病毒似乎在HC的发生发展中起作用，血浆中BK DNA的定量检测似乎是HCT受者BK病毒疾病的一个标志物。
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