Eddouks M, Maghrani M, Zeggwagh N-A, Haloui M, Michel J-B
UFR PNPE P.B. 21, Boutalamine, Errachidia 52000, Morocco.
J Ethnopharmacol. 2005 May 13;99(1):49-54. doi: 10.1016/j.jep.2005.01.050.
The hypotensive effect of an aqueous extract of Fraxinus excelsior L. was investigated in both normotensive (WKY) and spontaneously hypertensive rats (SHR). Daily oral administration of Fraxinus excelsior (20 mg/kg) aqueous extract for 3 weeks produced a significant decrease in systolic blood pressure (SBP) with variation coefficient (Delta%) of 13.5% in SHR (p<0.01) and 9% in WKY rats (p<0.05). The aqueous extract of Fraxinus excelsior significantly enhanced the urination in both SHR (p<0.05 compared to control) and WKY (p<0.05 compared to control). Irbesartan (Avapro), an angiotensin II antagonist, was used as reference drug. Furthermore, oral administration of aqueous Fraxinus excelsior extract at a dose of 20 mg/kg produced a significant increase in urinary excretion of sodium (p<0.01 compared to control), potassium (p<0.001 compared to control) and chlorides (p<0.01) in SHR rats. In normal rats, the aqueous Fraxinus excelsior extract administration induced a significant increase of the urinary elimination of sodium (p<0.05 compared to control), chlorides (p<0.01 compared to control) and potassium (p<0.01 versus control). While there were no significant changes in heart rate (HR) after Fraxinus excelsior treatment in both SHR and WKY rats, glomerular filtration rate (GFR) showed a significant increase in SH rats (p<0.001) after Fraxinus excelsior treatment. These results suggest that oral administration of aqueous extract of Fraxinus excelsior exhibited hypotensive and diuretic actions.
在正常血压的（WKY）大鼠和自发性高血压大鼠（SHR）中研究了欧洲白蜡树水提取物的降压作用。每天口服欧洲白蜡树（20mg/kg）水提取物，持续3周，收缩压（SBP）显著降低，SHR的变异系数（Δ%）为13.5%（p<0.01），WKY大鼠为9%（p<0.05）。欧洲白蜡树水提取物显著增加了SHR（与对照组相比，p<0.05）和WKY（与对照组相比，p<0.05）的尿量。厄贝沙坦（安博维），一种血管紧张素II拮抗剂，用作参考药物。此外，以20mg/kg的剂量口服欧洲白蜡树水提取物，使SHR大鼠的尿钠（与对照组相比，p<0.01）、钾（与对照组相比，p<0.001）和氯（p<0.01）排泄显著增加。在正常大鼠中，口服欧洲白蜡树水提取物导致尿钠（与对照组相比，p<0.05）、氯（与对照组相比，p<0.01）和钾（与对照组相比，p<0.01）的排泄显著增加。虽然在SHR和WKY大鼠中，欧洲白蜡树治疗后心率（HR）没有显著变化，但在SH大鼠中，欧洲白蜡树治疗后肾小球滤过率（GFR）显著增加（p<0.001）。这些结果表明，口服欧洲白蜡树水提取物具有降压和利尿作用。
