Eddouks M, Maghrani M, Louedec L, Haloui M, Michel J B
Faculty of Sciences and Techniques, BP 21, Errachidia, 52000, Morocco.
J Herb Pharmacother. 2007;7(2):65-77. doi: 10.1300/j157v07n02_05.
The antihypertensive and diuretic effects of the aqueous extract of Retama raetam Forssk. (RR) leaves were studied in both normotensive (WKY) and spontaneously hypertensive rats (SHR). In SHR rats, daily oral administration of RR (20 mg/kg) for three weeks exhibited a significant reduction in blood pressure. The systolic blood pressure decreased significantly from the seventh day (P < 0.01) and persisted through the end of treatment (P < 0.001) in SHR rats. The RR significantly enhanced the diuresis in WKY rats (P < 0.001). Furthermore, oral administration of RR at a dose of 20 mg/kg produced a significant increase on urinary excretion of sodium (P < 0.05), potassium (P < 0.01) and chlorides (P < 0.01) in SHR rats. In WKY rats, RR treatment induced a significant increase on urinary potassium elimination (P < 0.05) without affecting sodium and chloride excretion. Irbesartan (Avapro) 20 mg/kg (body weight), an angiotensin II receptor antagonist, was used as reference drug. No significant changes were noted in heart rate after RR treatment in SHR as well as in WKY rats. Glomerular filtration rate showed a significant increase after RR administration in WKY rats (P < 0.01) and a no significant increase in SHR rats. These results suggest that oral administration of aqueous RR extract exhibited antihypertensive and diuretic effects in SHR rats and diuretic action in WKY rats.
研究了刺蒺藜（Retama raetam Forssk.，RR）叶水提取物对正常血压大鼠（WKY）和自发性高血压大鼠（SHR）的降压和利尿作用。在SHR大鼠中，连续三周每日口服RR（20 mg/kg）可使血压显著降低。SHR大鼠的收缩压从第7天开始显著下降（P < 0.01），并持续至治疗结束（P < 0.001）。RR可显著增强WKY大鼠的利尿作用（P < 0.001）。此外，在SHR大鼠中，口服20 mg/kg剂量的RR可使尿钠（P < 0.05）、钾（P < 0.01）和氯（P < 0.01）的排泄显著增加。在WKY大鼠中，RR治疗可使尿钾排泄显著增加（P < 0.05），而不影响钠和氯的排泄。以20 mg/kg（体重）的血管紧张素II受体拮抗剂厄贝沙坦（安博维）作为参比药物。RR治疗后，SHR大鼠和WKY大鼠的心率均无显著变化。RR给药后，WKY大鼠的肾小球滤过率显著增加（P < 0.01），而SHR大鼠则无显著增加。这些结果表明，口服RR水提取物对SHR大鼠具有降压和利尿作用，对WKY大鼠具有利尿作用。
