Turkkan J S, Allen R P, Hienz R D
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Pharmacol Biochem Behav. 1992 Mar;41(3):567-72. doi: 10.1016/0091-3057(92)90374-o.
Spontaneous motor activity was measured in six baboons during chronic oral dosing with a diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Piezoelectric monitors sensitive to movement were attached to leather collars and were worn continuously by the baboons throughout the protocol. Baboons were made hypertensive during a preexperimental period by either 1) chronic administration of deoxycorticosterone acetate (DOCA)-salt or 2) surgical renal artery stenosis. Total inactive periods/day increased over baseline levels during diuretic alone and increased further during diuretic + verapamil combined. The total number of inactive periods/day returned toward baseline levels in the subsequent conditions of verapamil alone and baseline recovery. Activity levels decreased during combination dosing mainly during morning hours (0700-1100 h). Overall changes in activity occurred in the second week of dosing; this time period was found earlier to maximally decrease blood pressure and to impair behavioral performances.
在六只狒狒长期口服利尿剂（氢氯噻嗪/氨苯蝶啶）、钙通道阻滞剂（维拉帕米）以及两种药物联合使用期间，对其自发运动活动进行了测量。对运动敏感的压电监测器附着在皮制项圈上，在整个实验过程中，狒狒持续佩戴。在实验前期，通过以下两种方式使狒狒患上高血压：1）长期给予醋酸脱氧皮质酮（DOCA）-盐；2）进行外科肾动脉狭窄手术。单独使用利尿剂期间，每日总不活动期超过基线水平，在利尿剂 + 维拉帕米联合使用时进一步增加。在随后单独使用维拉帕米以及恢复到基线水平的情况下，每日不活动期总数恢复到基线水平。联合给药期间活动水平下降，主要发生在上午时段（0700 - 1100时）。活动的总体变化出现在给药的第二周；此前发现该时间段能最大程度降低血压并损害行为表现。
