Turkkan J S, Hienz R D
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Pharmacol Biochem Behav. 1991 Jan;38(1):55-62. doi: 10.1016/0091-3057(91)90589-t.
Behavioral performances of six baboons were tested during chronic oral dosing with diuretic (hydrochlorothiazide/triamterene), a calcium channel blocker (verapamil), and a combination of the two drugs. Reaction times and color matching-to-sample performances as well as physiological measures were obtained in deoxycorticosterone acetate (DOCA)-salt baboons and in renovascular hypertensive baboons. Combined diuretic and verapamil impaired color matching to a small degree in comparison to baseline performance, while drug administered alone had no effect. Weekly systolic and diastolic blood pressures decreased maximally from baseline during the drug combination period, and were accompanied by maximal increases in serum sodium. The largest behavioral impairments during combination dosing were observed for colors that were most difficult to discriminate during baseline. Significant positive correlations were found between systolic blood pressure and color matching accuracy. No differences between the animal hypertension groups were found as a function of drug condition either in physiological or behavioral responses. Only the combination of diuretic and verapamil produced a deleterious effect on color discrimination, which suggests further study of commonly administered drug combination therapies in hypertension.
在对六只狒狒进行慢性口服利尿剂（氢氯噻嗪/氨苯蝶啶）、钙通道阻滞剂（维拉帕米）以及这两种药物联合用药期间，对其行为表现进行了测试。在醋酸脱氧皮质酮（DOCA）-盐处理的狒狒和肾血管性高血压狒狒中获取了反应时间、颜色匹配样本表现以及生理指标。与基线表现相比，利尿剂和维拉帕米联合用药对颜色匹配有轻微损害，而单独给药则无影响。在联合用药期间，每周收缩压和舒张压从基线水平最大程度下降，同时血清钠最大程度升高。联合给药期间，在基线时最难区分的颜色出现了最大的行为损害。收缩压与颜色匹配准确性之间存在显著正相关。在生理或行为反应方面，未发现动物高血压组之间因药物情况而存在差异。只有利尿剂和维拉帕米联合用药对颜色辨别产生了有害影响，这表明需要进一步研究高血压中常用的联合药物治疗方法。
