Boggi U, Signori S, Vistoli F, Del Chiaro M, Pietrabissa A, Croce C, Barsotti M, Bartolo T Vanadia, Amorese G, Capocasale E, Della Valle R, Mazzoni M P, Mosca F
Centro Regionale di Riferimento per la Cura delle Malattie del Pancreas, University of Pisa, Pisa, Italy.
Transplant Proc. 2005 Mar;37(2):1262-4. doi: 10.1016/j.transproceed.2005.01.040.
This study compared the safety and efficacy of University of Wisconsin solution (UW) and Celsior solution (C) in pancreas transplantation (PTx).
A retrospective review of 154 PTx performed over a 61-month period included 77 grafts preserved with UW and 77 with C. The two groups were comparable for both donor and recipient characteristics.
After a mean cold ischemia time of 624 minutes (range 360 to 945 minutes) for UW versus 672 minutes (range 415 to 1005 minutes) for C (P = NS), no primary endocrine nonfunction occurred. Delayed endocrine function was diagnosed in two grafts in the UW group (2.6%) versus none in the C group (P = NS). After a minimum follow-up of 4 months (mean 26.5 +/- 15.2 months), 22 recipients (UW = 11 vs C = 11; P = NS) required relaparotomy. Overall, 18 pancreata were lost due to either patient death with functioning graft (UW = 4 vs C = 1; P = NS) or graft loss due to other reasons (UW = 8 vs C = 5; P = NS). Actuarial 1- and 5-year patient survival rates were 93.5% and 86.8% for UW compared with 98.7% and 98.7% for C (P = .04). Actuarial graft survival rates at the same times were 88.3% and 75.0% for UW compared with 90.4% and 90.4% for C (P = NS).
Within the range of cold ischemia times reported in this study, UW and C show similar safety and efficacy profiles for PTx.
本研究比较了威斯康星大学溶液（UW）和赛而西奥溶液（C）在胰腺移植（PTx）中的安全性和有效性。
对在61个月期间进行的154例胰腺移植进行回顾性分析，其中77例移植物用UW保存，77例用C保存。两组在供体和受体特征方面具有可比性。
UW组平均冷缺血时间为624分钟（范围360至945分钟），C组为672分钟（范围415至1005分钟）（P=无显著性差异），未发生原发性内分泌功能丧失。UW组有2例移植物被诊断为内分泌功能延迟（2.6%），C组无（P=无显著性差异）。在至少随访4个月（平均26.5±15.2个月）后，22例受者（UW=11例 vs C=11例；P=无显著性差异）需要再次剖腹手术。总体而言，18个胰腺丢失，原因包括有功能移植物的患者死亡（UW=4例 vs C=1例；P=无显著性差异）或其他原因导致的移植物丢失（UW=8例 vs C=5例；P=无显著性差异）。UW组1年和5年的患者精算生存率分别为93.5%和86.8%，C组分别为98.7%和98.7%（P=0.04）。同期UW组的移植物精算生存率分别为88.3%和75.0%，C组分别为90.4%和90.4%（P=无显著性差异）。
在本研究报告的冷缺血时间范围内，UW和C在胰腺移植中显示出相似的安全性和有效性。
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