老年供体肾移植：一项比较赛而斯欧液和UW液的前瞻性随机研究

Kidney transplantation from elderly donors: a prospective randomized study comparing celsior and UW solutions.

作者信息

Montalti R, Nardo B, Capocasale E, Mazzoni M P, Dalla Valle R, Busi N, Beltempo P, Bertelli R, Puviani L, Pacilè V, Fuga G, Faenza A

机构信息

Department of Surgery, Intensive Care Unit and Transplantations, University of Bologna, Bologna, Italy.

出版信息

Transplant Proc. 2005 Jul-Aug;37(6):2454-5. doi: 10.1016/j.transproceed.2005.06.030.

DOI:10.1016/j.transproceed.2005.06.030

PMID:16182706

Abstract

AIM

The aim of present study was to assess the effect of Celsior as compared with University of Wisconsin (UW) solution on immediate and long-term function of kidney transplants harvested from elderly donors.

METHODS

A prospective multicenter randomized study was designed to evaluate the efficacy of Celsior versus UW solution for the clinical preservation of the kidney. Fifty renal transplants were performed from donors over 60 years old. Twenty-five kidneys were stored in Celsior and 25 in UW solution. The groups were comparable with regard to donor and recipient characteristics. Renal function outcomes were compared by evaluating delayed graft function rates, daily urinary output, as well as the evolution of mean serum creatinine at 1, 3, 5, 7, and 15 days.

RESULTS

The warm ischemia time was 42.4 +/- 11 minutes among Celsior vs 46.9 +/- 17.9 minutes in the UW cohort (P = NS). The cold ischemia time was 18 +/- 4.5 hours in Celsior and 19 +/- 6.5 hours in UW (P = NS). Delayed graft function occurred in 48% of the Celsior group and in 52% of the UW group (P = NS). Mean serum creatinine levels and mean daily urinary output were also similar. One- and 5-year graft survivals of kidneys preserved with Celsior were 91.8% and 79.3% compared with 96% and 87.4% for UW without any significant statistical difference.

CONCLUSIONS

Our data show that the preservation of kidneys from elderly donors in Celsior solution is equivalent to that of UW solution.

摘要

目的

本研究旨在评估与威斯康星大学（UW）溶液相比，赛尔修斯（Celsior）溶液对老年供体肾移植的即刻和长期功能的影响。

方法

设计一项前瞻性多中心随机研究，以评估Celsior溶液与UW溶液对肾脏临床保存的疗效。对60岁以上的供体进行了50例肾移植。25个肾脏保存在Celsior溶液中，25个保存在UW溶液中。两组在供体和受体特征方面具有可比性。通过评估移植肾功能延迟恢复率、每日尿量以及术后1、3、5、7和15天血清肌酐均值的变化来比较肾功能结果。

结果

Celsior组的热缺血时间为42.4±11分钟，而UW组为46.9±17.9分钟（P=无显著性差异）。Celsior组的冷缺血时间为18±4.5小时，UW组为19±6.5小时（P=无显著性差异）。Celsior组48%出现移植肾功能延迟恢复，UW组为52%（P=无显著性差异）。血清肌酐均值和每日平均尿量也相似。用Celsior溶液保存的肾脏1年和5年移植存活率分别为91.8%和79.3%，而UW溶液组分别为96%和87.4%，无显著统计学差异。