使用威斯康星大学溶液和赛而西奥溶液保存胰腺。

Pancreas preservation with University of Wisconsin and Celsior solutions.

作者信息

Boggi U, Coletti L, Vistoli F, Del Chiaro M, Signori S, Croce C, Bartolo T Vanadia, Pietrabissa A, Marchetti P, Capocasale E, Dalla Valle R, Mazzoni M P, Mosca F

机构信息

Divisione di Chirurgia Generale e Trapianti, Università di Pisa, Pisa, Italy.

出版信息

Transplant Proc. 2004 Apr;36(3):563-5. doi: 10.1016/j.transproceed.2004.03.078.

DOI:10.1016/j.transproceed.2004.03.078

PMID:15110594

Abstract

BACKGROUND

Although the use of Celsior has been recently described for heart, lung, liver, and kidney transplantation, no data are available on its use for clinical pancreas preservation.

METHODS

We herein describe the results of 112 pancreas transplants preserved with either University of Wisconsin (UW; (n = 56) or Celsior (n = 56) solution at two Italian transplant centers. The groups were comparable with regard to all donor and recipient characteristics.

RESULTS

Mean cold and warm ischemia times were 10.1 +/- 2.2 hours and 37.2 +/- 8.2 minutes for UW compared to 10.8 +/- 2.4 hours and 38.3 +/- 6.7 minutes for Celsior (P = NS). Delayed endocrine pancreas function was recorded in two UW-preserved grafts (3.6%). Actuarial 1-year patient survival was 94.6% for UW as compared with 100% for Celsior (P = NS). Equivalent graft survival figures were 91.0% for UW as compared with 96.4% for Celsior (P = NS).

CONCLUSIONS

Within the range of cold ischemia times reported in this study, UW and Celsior solutions have similar safety profiles for pancreas transplantation.

摘要

背景

尽管最近已有关于Celsior溶液用于心脏、肺、肝脏和肾脏移植的报道，但尚无其用于临床胰腺保存的数据。

方法

我们在此描述了在两个意大利移植中心用威斯康星大学（UW；n = 56）或Celsior溶液（n = 56）保存的112例胰腺移植的结果。两组在所有供体和受体特征方面具有可比性。

结果

UW组的平均冷缺血时间和热缺血时间分别为10.1±2.2小时和37.2±8.2分钟，而Celsior组分别为10.8±2.4小时和38.3±6.7分钟（P =无显著性差异）。在两个用UW溶液保存的移植物中记录到延迟的内分泌胰腺功能（3.6%）。UW组1年患者精算生存率为94.6%，而Celsior组为100%（P =无显著性差异）。UW组和Celsior组的移植物生存率相当，分别为91.0%和96.4%（P =无显著性差异）。