Gaultier E, Bonnafous L, Bougrat L, Lafont C, Pageat P
Phérosynthèse, Le Rieu Neuf, 84490, Saint-Saturin-les-Apt, France.
Vet Rec. 2005 Apr 23;156(17):533-8. doi: 10.1136/vr.156.17.533.
Sixty-seven dogs that showed signs of distress when separated from their owners (destructiveness, excessive vocalisation and house soiling) and hyperattachment were used in a randomised, blind trial to assess the potential value of a dog-appeasing pheromone in reducing the unacceptable behaviours. For ethical reasons, there was no placebo group and the effects of the pheromone were compared with the effects of clomipramine which is regularly used to treat this type of problem. The undesirable behaviours decreased in both groups, but the overall assessment by the owners indicated that there was no significant difference between the two treatments, although there were fewer undesirable events in the dogs treated with the pheromone, and the administration of the pheromone appeared to be more convenient.
67只在与主人分开时表现出痛苦迹象（具有破坏性、过度吠叫和在家中弄脏）以及过度依恋的狗被用于一项随机、盲法试验，以评估一种犬安抚信息素在减少不可接受行为方面的潜在价值。出于伦理原因，没有设立安慰剂组，而是将信息素的效果与常用于治疗这类问题的氯米帕明的效果进行比较。两组中不良行为均有所减少，但主人的总体评估表明，两种治疗方法之间没有显著差异，不过使用信息素治疗的狗出现的不良事件较少，而且信息素的使用似乎更方便。
