Katiyar A K, Vegad J L, Awadhiya R P
Department of Pathology, College of Veterinary Science and Animal Husbandry, Jabalpur, India.
Res Vet Sci. 1992 Mar;52(2):154-61. doi: 10.1016/0034-5288(92)90004-l.
The permeability response was examined in chickens following intradermal injection of Escherichia coli endotoxin. The 'dye' and 'colloidal carbon' techniques were employed. The endotoxin evoked a monophasic response of immediate-prolonged type. The increase in vascular permeability was confined to venules and small veins only, indicating its mediation by endogenous permeability factors. The carbon labelling exhibited arboreal, disjointed and rectangular to hexagonal patterns. Histologically, a striking feature of the reaction was an accumulation of basophils in unusually large numbers. No other type of stimulus appears to induce basophilic response of a similar magnitude in the chicken. The results suggest that endotoxin, being a bacterial product, may exert a chemotactic effect on basophils. Hyperaemia, oedema, necrosis and formation of perivascular lymphoid aggregates were also recognised.
在给鸡皮内注射大肠杆菌内毒素后，检测其通透性反应。采用了“染料”和“胶体碳”技术。内毒素引发了即刻-持续型的单相反应。血管通透性增加仅局限于小静脉和小静脉，表明其由内源性通透性因子介导。碳标记呈现出树枝状、不连续以及矩形至六边形的模式。组织学上，该反应的一个显著特征是嗜碱性粒细胞大量积聚。似乎没有其他类型的刺激能在鸡身上诱导出类似程度的嗜碱性粒细胞反应。结果表明，作为一种细菌产物，内毒素可能对嗜碱性粒细胞发挥趋化作用。还观察到了充血、水肿、坏死以及血管周围淋巴样聚集物的形成。
