HIV感染期间脑脊液中的T细胞活化和记忆表型
T-cell activation and memory phenotypes in cerebrospinal fluid during HIV infection.
作者信息
Neuenburg Jutta K, Cho Tracey A, Nilsson Annelie, Bredt Barry M, Hebert Samuel J, Grant Robert M, Price Richard W
机构信息
Department of Neurology, San Francisco General Hospital, General Clinical Research Center at the University of California, San Francisco, CA 94158, USA.
出版信息
J Acquir Immune Defic Syndr. 2005 May 1;39(1):16-22. doi: 10.1097/01.qai.0000155036.03004.a0.
We characterized T cell phenotypes in 74 paired blood and cerebrospinal fluid (CSF) samples of HIV-infected and uninfected persons using four-color flow cytometry. CD4+ and CD8+ T cells subsets were further characterized by identifying activated/resting and memory/naive subsets in CSF and blood using the markers CD38/HLA-DR and CD45RA/CD62L, respectively. With and without HIV-infection, the proportion of CD4+ T cells and memory T cells among T cells in CSF was higher compared to blood. In HIV-infection, activated CD4+ and CD8+ T cells in CSF were more abundant than in uninfected controls. As expected, combination antiretroviral therapy (ART) reduced T cell activation in CSF and blood.
我们使用四色流式细胞术对74例HIV感染者和未感染者配对的血液和脑脊液（CSF）样本中的T细胞表型进行了表征。通过分别使用标记物CD38/HLA-DR和CD45RA/CD62L在脑脊液和血液中鉴定活化/静息以及记忆/初始亚群，进一步对CD4+和CD8+ T细胞亚群进行了表征。无论是否感染HIV，脑脊液中T细胞中的CD4+ T细胞和记忆T细胞比例均高于血液。在HIV感染中，脑脊液中活化的CD4+和CD8+ T细胞比未感染对照组更为丰富。正如预期的那样，联合抗逆转录病毒疗法（ART）降低了脑脊液和血液中的T细胞活化。
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