在开始接受抗逆转录病毒治疗的 HIV 感染者中，脑脊液中独特的细胞免疫特性与认知功能相关。
Distinct cellular immune properties in cerebrospinal fluid are associated with cognition in HIV-infected individuals initiating antiretroviral therapy.
机构信息
Emory University School of Medicine, Atlanta, GA, USA.
New York University Vaccine Center and Department of Medicine, New York University School of Medicine, New York, NY, USA.
出版信息
J Neuroimmunol. 2020 Jul 15;344:577246. doi: 10.1016/j.jneuroim.2020.577246. Epub 2020 Apr 27.
Abstract
We examined the relationship between CSF immune cells and neurocognition and neuronal damage in HIV+ individuals before and after initiating antiretroviral therapy. Multivariate analysis at baseline indicated that greater CD4+ T cell abundance was associated with better cognition (p = .017), while higher CSF HIV RNA was associated with increased neuronal damage (p = .014). Following 24 weeks of antiretroviral therapy, CD8+ T cells, HLA-DR expressing CD4+ and CD8+ T cells, B cells, NK cells, and non-classical monocyte percentage decreased in CSF. Female gender was negatively associated with cognitive performance over time, as was higher percentage of HLA-DR expressing CD8+ T cells at baseline.
摘要
我们研究了 HIV 感染者在开始抗逆转录病毒治疗前后脑脊液免疫细胞与神经认知和神经元损伤之间的关系。基线时的多变量分析表明，CD4+T 细胞数量较多与认知功能较好相关（p=0.017），而脑脊液 HIV RNA 水平较高与神经元损伤增加相关（p=0.014）。在接受 24 周抗逆转录病毒治疗后，CSF 中的 CD8+T 细胞、表达 HLA-DR 的 CD4+和 CD8+T 细胞、B 细胞、NK 细胞和非经典单核细胞比例下降。女性性别与认知表现随时间的变化呈负相关，基线时表达 HLA-DR 的 CD8+T 细胞比例较高也是如此。
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