Hansen Darren B, Joullie Madeleine M
Department of Chemistry, University of Pennsylvania, Philadelphia, 19104-6326, USA.
Chem Soc Rev. 2005 May;34(5):408-17. doi: 10.1039/b315496n. Epub 2005 Feb 11.
Following its discovery by Siegfried Ruhemann in 1910, ninhydrin rapidly became a practical analytical tool. In 1954 it was found to be an important reagent to develop fingerprints on porous surfaces. Since its use in forensic chemistry, many efforts have focused on improving the reagent. Many of the shortcomings of ninhydrin have been met by the synthesis of a variety of ninhydrin analogues. This tutorial review provides a short introduction to ninhydrin and highlights the different synthetic approaches used in the development of analogues for the detection of latent fingerprints.
1910年被西格弗里德·鲁赫曼发现后，茚三酮迅速成为一种实用的分析工具。1954年，它被发现是用于在多孔表面显出手印的重要试剂。自其在法医化学中使用以来，许多努力都集中在改进该试剂上。茚三酮的许多缺点已通过合成多种茚三酮类似物得到解决。本教程综述简要介绍了茚三酮，并重点介绍了用于开发检测潜在指纹类似物的不同合成方法。
