Zec Ronald F, Burkett Nicole R
Center for Alzheimer Disease and Related Disorders, Department of Neurology, Southern Illinois University School of Medicine, Springfield, IL 62794, USA.
NeuroRehabilitation. 2008;23(5):425-38.
This paper discusses the various pharmacological and behavioral treatments for the cognitive, emotional, and behavioral symptoms of Alzheimer disease (AD). The medications that are currently FDA-approved for the treatment of the cognitive/functional deficits of AD will first be discussed. Next, neuropsychiatric behavioral disturbances, including hallucinations and delusions, agitation and aggression, activity disturbances, depression, and anxiety will be described along with treatment interventions. Sleep disturbance and its treatment in AD and the issue of fitness to drive a motor vehicle are also reviewed. Principles of behavioral management, tips for communication, and recommendations for caregivers are discussed. Lastly, risk and protective factors and their relevance to delaying the expression of dementia are also examined.
本文讨论了针对阿尔茨海默病（AD）认知、情感和行为症状的各种药物及行为治疗方法。首先将讨论目前美国食品药品监督管理局（FDA）批准用于治疗AD认知/功能缺陷的药物。接下来，将描述神经精神行为障碍，包括幻觉和妄想、激越和攻击行为、活动障碍、抑郁和焦虑以及治疗干预措施。还将回顾AD中的睡眠障碍及其治疗以及驾驶机动车的适宜性问题。讨论了行为管理原则、沟通技巧以及对护理人员的建议。最后，还研究了风险和保护因素及其与延缓痴呆症表现的相关性。
